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Let's be honest, my interest in science has diminished rapidly since I stopped taking classes. I guess that not being immersed in at least some aspect of the field has caused that portion of my brain to atrophy. I used to read New Scientist, Scientific American, Discover, etc every month and now I'll be lucky to catch a news article about NASA on Google News.

Nevertheless, this article off Fark caught my eye: The 125 big questions that face scientific inquiry over the next quarter-century. Intriguing, really.